Multiparametric [18F]F-AraG Imaging in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)
Status:
NOT_YET_RECRUITING
Trial end date:
2029-12-01
Target enrollment:
Participant gender:
Summary
This study uses total-body \[F\]F-AraG PET/CT imaging to investigate immune activation and vascular changes in individuals with post-acute sequelae of SARS-CoV-2 infection (PASC), also known as Long COVID. Participants will undergo dynamic PET/CT imaging along with blood biomarker assessments and symptom evaluations. The study aims to characterize sites of immunological perturbation, correlate PET imaging findings with peripheral blood markers, and evaluate longitudinal changes in tissue-based immune activity in relation to symptom patterns over time. Data from this study will improve understanding of tissue-level immune dysregulation in PASC and support future clinical tools for assessing and managing this condition.
Phase:
EARLY_PHASE1
Details
Lead Sponsor:
University of California, Davis
Collaborators:
National Institute of Allergy and Infectious Diseases (NIAID) University of California, San Francisco